Migratory aortitis associated with granulocyte-colony-stimulating factor

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Abstract

We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.

Original languageEnglish
Pages (from-to)1559-1563
Number of pages5
JournalInternal Medicine
Volume59
Issue number12
DOIs
Publication statusPublished - 2020 Jun 15
Externally publishedYes

Keywords

  • Aortitis
  • Chemotherapy
  • Granulocyte-colony-stimulating factor
  • Migratory aortitis

ASJC Scopus subject areas

  • Internal Medicine

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