Migration of neutrophils from the lung into the pleural space after lung resection in humans and rabbits

T. Sakuma, H. Kubo, T. Tanita, K. Koike, S. Fujimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The origin of neutrophils that are found in pleural effusions after pulmonary resection is unknown. We measured neutrophil counts in pleural effusion sequentially for 48 h in patients who had undergone partial resection or pneumonectomy. Additionally, we measured neutrophil counts in the pleural effusions separately from the visceral pleura and parietal pleura in rabbits. In humans, we found that the maximum neutrophil counts in pleural effusion occurred more often in the patients who underwent partial resection (11.7 ± 6.0 x 104 cells/μL) than in the patients who underwent pneumonectomy (3.7 ± 1.2 x 104 cells/μL). There was no difference between neutrophil counts in blood of pneumonectomy group and that of the partial resection group. In rabbits, neutrophil counts were 1.5 times greater in the pleural effusion derived from the lung than in that derived from the parietal pleura. We conclude that movement of neutrophils occurs primarily from the lung into the pleural space after lung resection in humans and rabbits.

Original languageEnglish
Pages (from-to)812-818
Number of pages7
JournalChest
Volume102
Issue number3
DOIs
Publication statusPublished - 1992 Jan 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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