Migration of Deformable Vesicles Induced by Ionic Stimuli

Atsuji Kodama, Mattia Morandi, Ryuta Ebihara, Takehiro Jimbo, Masayuki Toyoda, Yuka Sakuma, Masayuki Imai, Nicolas Puff, Miglena I. Angelova

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have investigated the dynamics of phospholipid vesicles composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine triggered by ionic stimuli using electrolytes such as CaCl2, NaCl, and NaOH. The ionic stimuli induce two characteristic vesicle dynamics, deformation due to the ion binding to the lipids in the outer leaflet of the vesicle and migration due to the concentration gradient of ions, that is, diffusiophoresis or the interfacial energy gradient mechanism. We examined the deformation pathway for each electrolyte as a function of time and analyzed it based on the surface dissociation model and the area difference elasticity model, which reveals the change of the cross-sectional area of the phospholipid by the ion binding. The metal ions such as Ca2+ and Na+ encourage inward budding deformation by decreasing the cross-sectional area of a lipid, whereas the hydroxide ion (OH-) encourages outward budding deformation by increasing the cross-sectional area of a lipid. When we microinjected these electrolytes toward the vesicles, a strong coupling between the deformation and the migration of the vesicle was observed for CaCl2 and NaOH, whereas for NaCl, the coupling was very weak. This difference probably originates from the binding constants of the ions.

Original languageEnglish
Pages (from-to)11484-11494
Number of pages11
JournalLangmuir
Volume34
Issue number38
DOIs
Publication statusPublished - 2018 Sep 25

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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    Kodama, A., Morandi, M., Ebihara, R., Jimbo, T., Toyoda, M., Sakuma, Y., Imai, M., Puff, N., & Angelova, M. I. (2018). Migration of Deformable Vesicles Induced by Ionic Stimuli. Langmuir, 34(38), 11484-11494. https://doi.org/10.1021/acs.langmuir.8b02105