MIDA1, a protein associated with Id, regulates cell growth

W. Shoji, T. Inoue, T. Yamamoto, M. Obinata

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

We have isolated cDNA clone encoding a protein that can associate with Id, a helix-loop-helix (HLH) protein. This protein is named MIDA1 (mouse Id associate 1), and its predicted amino acid sequence consists of Zuotin (a putative Z-DNA binding protein in yeast) homology region and tryptophan- mediated repeats similar to c-Myb oncoprotein. MIDA1 associates with the HLH region of Id with the conserved region adjacent to eukaryotic DnaJ conserved motif within the Zuotin homology region, although it does not have any canonical HLH motif. The addition of antisense oligonucleotide of MIDA1 inhibited growth of murine erythroleukemia cells without interfering with erythroid differentiation, indicating that it regulates cell growth.

Original languageEnglish
Pages (from-to)24818-24825
Number of pages8
JournalJournal of Biological Chemistry
Volume270
Issue number42
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'MIDA1, a protein associated with Id, regulates cell growth'. Together they form a unique fingerprint.

Cite this