Microvascular disorders induced by malaria infected red blood cells: A computational mechanical study using the biological particle method

T. Yamaguchi, H. Kondo, Y. Imai, T. Ishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We simulated malarial microvascular blood flow disturbances by using a new particle method of biological solid-fluid interaction analysis especially developed for the analysis of malaria infection. Particle based spatial discretization and the sub time step time integration could provide us with stable computations for micro scale blood flow involving interaction with many cells. We performed numerical simulation of the stretching of infected red blood cells and the results agreed well with experimental results. Our model successfully simulated the flow of infected red blood cells into narrow channels.

Original languageEnglish
Title of host publicationModelling in Medicine and Biology VIII
Pages49-55
Number of pages7
DOIs
Publication statusPublished - 2009
Event8th International Conference on Modelling in Medicine and Biology, BIOMED 2009 - Crete, Greece
Duration: 2009 May 262009 May 28

Publication series

NameWIT Transactions on Biomedicine and Health
Volume13
ISSN (Print)1743-3525

Other

Other8th International Conference on Modelling in Medicine and Biology, BIOMED 2009
CountryGreece
CityCrete
Period09/5/2609/5/28

Keywords

  • Computational fluid dynamics
  • Malaria
  • Mechanical properties of cell membrane
  • Microcirculation
  • Particle method
  • Red blood cell

ASJC Scopus subject areas

  • Modelling and Simulation
  • Biomedical Engineering
  • Computer Science Applications
  • Public Health, Environmental and Occupational Health

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