Microtubule shuttles on kinesin-coated glass micro-wire tracks

Kyongwan Kim, Andrew L. Liao, Aurélien Sikora, Daniel Oliveira, Hikaru Nakazawa, Mitsuo Umetsu, Izumi Kumagai, Tadafumi Adschiri, Wonmuk Hwang, Winfried Teizer

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Gliding of microtubule filaments on surfaces coated with the motor protein kinesin has potential applications for nano-scale devices. The ability to guide the gliding direction in three dimensions allows the fabrication of tracks of arbitrary geometry in space. Here, we achieve this by using kinesin-coated glass wires of micrometer diameter range. Unlike previous methods in which the guiding tracks are fixed on flat two-dimensional surfaces, the flexibility of glass wires in shape and size facilitates building in-vitro devices that have deformable tracks.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalBiomedical microdevices
Volume16
Issue number4
DOIs
Publication statusPublished - 2014 Aug

Keywords

  • Glass micro-wire
  • Kinesin
  • Lab-on-a-chip
  • Microtubule
  • Molecular delivery
  • Molecular motility

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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