Microscale flow dynamics of red blood cells in microchannels: An experimental and numerical analysis

R. Lima, M. Nakamura, T. Omori, T. Ishikawa, S. Wada, T. Yamaguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

The blood flow dynamics in microcirculation depends strongly on the motion, deformation and interaction of red blood cells (RBCs) within the microvessel. We present confocal micro-PTV measurements on the motion of individual RBCs through a circular polydimethysiloxane (PDMS) microchannel. The RBC radial displacement and dispersion calculated from these measurements show that the RBC paths are strongly dependent on the both Hct and plasma layer. In order to obtain more detailed information of the non-Newtonian property of blood a novel computational scheme is also described. The simulated flow dynamics were in good agreement with the Casson flow model and in vivo observations. In the near future by comparing both results we hope to clarify a variety of complex phenomena occurring at the microscale level.

Original languageEnglish
Title of host publicationAdvances in Computational Vision and Medical Image Processing
Subtitle of host publicationMethods and Applications
EditorsJoao Manuel, R.S. Tavares, R.M. Natal Jorge
PublisherSpringer
Pages203-220
Number of pages18
ISBN (Print)9781402090851
DOIs
Publication statusPublished - 2009
Event1st ECCOMAS Thematic Conference on Computational Vision and Medical Image processing, VIPimage 2007 - Porto, Portugal
Duration: 2007 Oct 172007 Oct 19

Publication series

NameComputational Methods in Applied Sciences
Volume13
ISSN (Print)1871-3033

Other

Other1st ECCOMAS Thematic Conference on Computational Vision and Medical Image processing, VIPimage 2007
CountryPortugal
CityPorto
Period07/10/1707/10/19

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Modelling and Simulation
  • Biomedical Engineering
  • Computer Science Applications
  • Fluid Flow and Transfer Processes
  • Computational Mathematics
  • Electrical and Electronic Engineering

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