Microscale flow dynamics of red blood cells in microchannels: An experimental and numerical analysis

R. Lima, C. S. Fernandes, R. Dias, T. Ishikawa, Y. Imai, T. Yamaguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW®, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.

Original languageEnglish
Title of host publicationComputational Vision and Medical Image Processing
EditorsJoão Manuel Tavares, R.M. Natal Jorge
PublisherSpringer Netherland
Pages297-309
Number of pages13
ISBN (Print)9789400700109
DOIs
Publication statusPublished - 2011 Jan 1
Event2nd ECCOMAS Thematic Conference on Computational Vision andMedical Image processing, VIPimage 2009 - Porto, Portugal
Duration: 2009 Oct 142009 Oct 16

Publication series

NameComputational Methods in Applied Sciences
Volume19
ISSN (Print)1871-3033

Other

Other2nd ECCOMAS Thematic Conference on Computational Vision andMedical Image processing, VIPimage 2009
CountryPortugal
CityPorto
Period09/10/1409/10/16

Keywords

  • Bifurcation
  • Blood flow
  • Microchannel
  • Microvascular networks

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Modelling and Simulation
  • Biomedical Engineering
  • Computer Science Applications
  • Fluid Flow and Transfer Processes
  • Computational Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Lima, R., Fernandes, C. S., Dias, R., Ishikawa, T., Imai, Y., & Yamaguchi, T. (2011). Microscale flow dynamics of red blood cells in microchannels: An experimental and numerical analysis. In J. M. Tavares, & R. M. N. Jorge (Eds.), Computational Vision and Medical Image Processing (pp. 297-309). (Computational Methods in Applied Sciences; Vol. 19). Springer Netherland. https://doi.org/10.1007/978-94-007-0011-6_17