Microscale biomaterials for tissue engineering

Ian Wheeldon; Javier Fernandez; Hojae Bae; Hirokazu Kaji; Ali Khademhosseini

doi:10.1007/978-3-7091-0385-2_5

Microscale biomaterials for tissue engineering

Ian Wheeldon, Javier Fernandez, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini

ENG - Finemechanics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

Microscale and high throughput technologies are powerful tools for addressing many of the challenges in the field of tissue engineering. In this chapter, we present an overview of these technologies and their applications in controlling the cellular microenviroment for tissue engineering applications. We focus on concepts and techniques that can be used to create two-and three-dimensional tissue engineering substrates and scaffolds. Common to these techniques is the ability to control one or more aspects of the cellular microenvironment, including chemical and mechanical cues, cell-cell, cell-matrix, and cell-soluble factor interactions. We also discuss recent developments in high throughput techniques that are used to explore the vast number of combinations of factors that comprise the cellular microenvironment.

Original language	English
Title of host publication	Biomaterials for Tissue Engineering Applications
Subtitle of host publication	A Review of the Past and Future Trends
Publisher	Springer
Pages	119-138
Number of pages	20
ISBN (Print)	9783709103845
DOIs	https://doi.org/10.1007/978-3-7091-0385-2_5
Publication status	Published - 2011 Dec 1

Keywords

Cellular microenvironment
High throughput arrays
Microfabrication
Stem cells

ASJC Scopus subject areas

Materials Science(all)
Chemistry(all)

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10.1007/978-3-7091-0385-2_5

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AU - Wheeldon, Ian

AU - Fernandez, Javier

AU - Bae, Hojae

AU - Kaji, Hirokazu

AU - Khademhosseini, Ali

PY - 2011/12/1

Y1 - 2011/12/1

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AB - Microscale and high throughput technologies are powerful tools for addressing many of the challenges in the field of tissue engineering. In this chapter, we present an overview of these technologies and their applications in controlling the cellular microenviroment for tissue engineering applications. We focus on concepts and techniques that can be used to create two-and three-dimensional tissue engineering substrates and scaffolds. Common to these techniques is the ability to control one or more aspects of the cellular microenvironment, including chemical and mechanical cues, cell-cell, cell-matrix, and cell-soluble factor interactions. We also discuss recent developments in high throughput techniques that are used to explore the vast number of combinations of factors that comprise the cellular microenvironment.

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KW - Microfabrication

KW - Stem cells

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