Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease

Takahiro Kimura, Kaori Goto, Kazuro Yabuki, Nobuhisa Mizuki, Gen Tamiya, Masahiro Sato, Minoru Kimura, Hidetoshi Inoko, Shigeaki Ohno

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36 Citations (Scopus)

Abstract

Behcet's disease (BD) is known to be associated with HLA-B51. In order to investigate the influence of the MICB gene, located about 120 kb centromeric of the HLA-B gene, on the susceptibility to BD, (CA/TG) dinucleotide repeat microsatellite polymorphism in intron 1 of the MICB gene was investigated among 77 Japanese patients with BD, 60 randomly selected controls and 28 HLA-B51-positive unrelated healthy controls. There was no significant difference in the phenotype frequency of the microsatellite polymorphism between the BD patients and controls. This result suggests that the MICB gene itself is not responsible for the development of BD, and that the candidate gene(s) for BD is located between the MICA and HLA-C genes.

Original languageEnglish
Pages (from-to)500-502
Number of pages3
JournalHuman Immunology
Volume59
Issue number8
DOIs
Publication statusPublished - 1998 Aug 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kimura, T., Goto, K., Yabuki, K., Mizuki, N., Tamiya, G., Sato, M., Kimura, M., Inoko, H., & Ohno, S. (1998). Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease. Human Immunology, 59(8), 500-502. https://doi.org/10.1016/S0198-8859(98)00047-0