Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

Teiko Kimpara, Atsushi Takeda, Koichi Watanabe, Yasuto Itoyama, Shuntaro Ikawa, Minro Watanabe, Hiroyuki Arai, Hidetada Sasaki, Susumu Higuchi, Naoshi Okita, Sadao Takase, Hiroshi Saito, Kazuhiro Takahashi, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)

Abstract

Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-l (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)(n), repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalHuman Genetics
Volume100
Issue number1
DOIs
Publication statusPublished - 1997 Jul

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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