Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

Masato Takeda, Mihoko Kikuchi, Ratawan Ubalee, Kesara Na-Bangchang, Ronnatrai Ruangweerayut, Shigeki Shibahara, So Ichi Imai, Kenji Hirayama

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P<0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.

Original languageEnglish
Pages (from-to)268-271
Number of pages4
JournalJapanese journal of infectious diseases
Volume58
Issue number5
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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