Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

Masato Takeda; Mihoko Kikuchi; Ratawan Ubalee; Kesara Na-Bangchang; Ronnatrai Ruangweerayut; Shigeki Shibahara; So Ichi Imai; Kenji Hirayama

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

Masato Takeda, Mihoko Kikuchi, Ratawan Ubalee, Kesara Na-Bangchang, Ronnatrai Ruangweerayut, Shigeki Shibahara, So Ichi Imai, Kenji Hirayama

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)_n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)_n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)_n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)_n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P<0.008, OR = 3.14). Thus, short (GT)_n alleles represent a genetic risk factor for CM.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Japanese journal of infectious diseases
Volume	58
Issue number	5
Publication status	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar",

abstract = "Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P<0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.",

author = "Masato Takeda and Mihoko Kikuchi and Ratawan Ubalee and Kesara Na-Bangchang and Ronnatrai Ruangweerayut and Shigeki Shibahara and Imai, {So Ichi} and Kenji Hirayama",

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T1 - Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

AU - Takeda, Masato

AU - Kikuchi, Mihoko

AU - Ubalee, Ratawan

AU - Na-Bangchang, Kesara

AU - Ruangweerayut, Ronnatrai

AU - Shibahara, Shigeki

AU - Imai, So Ichi

AU - Hirayama, Kenji

PY - 2005

Y1 - 2005

N2 - Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P<0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.

AB - Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P<0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.

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AN - SCOPUS:27744595458

SN - 1344-6304

VL - 58

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JO - Japanese medical journal

JF - Japanese medical journal

IS - 5

ER -

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

Abstract

ASJC Scopus subject areas

UN SDGs

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