Microsatellite instability in gonadal tumors of XY pure gonadal dysgenesis patients

T. Funato, S. Uehara, M. Takahashi, K. Kozawa, J. Satoh, T. Sasaki, M. Kaku

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To investigate genetic alternation accompanied by malignant transformation in gonadal tumors of XY pure gonadal dysgenesis patients, we investigated microsatellite instability in the hMSH1, hMSH2, TP53, and DCC loci, and ras mutations in two patients. The gonadal tumors from the patients were combined gonadoblastoma and dysgerminoma. Microsatellite instability and/or loss of heterozygotes (LOH) at hMSH1, hMSH2, and TP53 were detected in the dysgerminoma lesions of the both patients, but were not observed in any normal tissues. In the analyses of the H-, K-, or N-ras genes, where specific mutations have been frequently reported, no mutations were observed in the tumors. It is suggested therefore that microsatellite instability plays an important role in malignant transformation of gonadal tumors in patients with XY pure gonadal dysgenesis.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume12
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Dysgerminoma
  • Gonadoblastoma
  • Microsatellite instability
  • Ras mutation
  • XY pure gonadal dysgenesis

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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