Microreactor for synthesis via intermediates with assembled units enabling rapid mixing and heat transfer and short residence time

Nobuaki Aoki, Ryouhei Kitajima, Chiharu Itoh, Kazuhiro Mae

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This paper describes a reactor for multi-step syntheses via intermediates with improved selectivity of desired products. This reactor is referred as assembled reactor. This reactor consists of mixing, residence time and heat exchange units. Connection of these units forms a module for a single reaction. Repeated joints of modules enable the reactor to be used in multi-step syntheses. Mixing and heat transfer rate of the assembled reactor was evaluated. This reactor enabled rapid mixing under the total flow rates of more than 30 mL/min and heat transfer efficiency of the order of 10 K per 10 ms in the heat exchange of fluids with temperature difference of 20-40 K. This reactor was also applied to the synthesis of bromobenzene via p-bromophenyllithium and gave the product yield more than 80%. Copyright (2008) by the American Institute of Chemical Engineers. All rights reserved.

    Original languageEnglish
    Title of host publication10th International Conference on Microreaction Technology, IMRET 2008 - Topical Conference at the 2008 AIChE Spring National Meeting
    PublisherAmerican Institute of Chemical Engineers
    Pages10-17
    Number of pages8
    ISBN (Print)9781605602110
    Publication statusPublished - 2008 Jan 1
    Event10th International Conference on Microreaction Technology, IMRET 2008 - Topical Conference at the 2008 AIChE Spring National Meeting - New Orleans, LA, United States
    Duration: 2008 Apr 12008 Apr 4

    Publication series

    Name10th International Conference on Microreaction Technology, IMRET 2008 - Topical Conference at the 2008 AIChE Spring National Meeting

    Other

    Other10th International Conference on Microreaction Technology, IMRET 2008 - Topical Conference at the 2008 AIChE Spring National Meeting
    Country/TerritoryUnited States
    CityNew Orleans, LA
    Period08/4/108/4/4

    Keywords

    • Assembled units
    • Heat transfer
    • Mixing
    • Residence time
    • Synthesis via intermediates

    ASJC Scopus subject areas

    • Fluid Flow and Transfer Processes

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