TY - JOUR
T1 - Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells
AU - Ino, Kosuke
AU - Şen, Mustafa
AU - Shiku, Hitoshi
AU - Matsue, Tomokazu
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (A) (no. 16H02280), a Grant-in-Aid for Scientific Research (B) (no. 15H035420), and a Grant-in-Aid for Young Scientists (A) (no. 15H05415) from the Japan Society for the Promotion of Science (JSPS). This work was also supported by Special Coordination Funds for Promoting Science and Technology, Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program from the Japan Science and Technology Agency. This work was also supported by the Asahi Glass Foundation.
Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017/12/7
Y1 - 2017/12/7
N2 - Herein, we present an overview of recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells. First, we discuss probe devices: a general outline, evaluation of O2 consumption, enzyme-modified electrodes, evaluation of endogenous enzyme activity, and the collection of cell components from cell aggregates are discussed. The next section is focused on integrated chip devices: a general outline, electrode array devices, smart electrode array devices, droplet detection of 3D cultured cells, cell manipulation using dielectrophoresis (DEP), and electrodeposited hydrogels used for fabrication of 3D cultured cells on chip devices are discussed. Finally, we provide a summary and discussion of future directions of research in this field.
AB - Herein, we present an overview of recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells. First, we discuss probe devices: a general outline, evaluation of O2 consumption, enzyme-modified electrodes, evaluation of endogenous enzyme activity, and the collection of cell components from cell aggregates are discussed. The next section is focused on integrated chip devices: a general outline, electrode array devices, smart electrode array devices, droplet detection of 3D cultured cells, cell manipulation using dielectrophoresis (DEP), and electrodeposited hydrogels used for fabrication of 3D cultured cells on chip devices are discussed. Finally, we provide a summary and discussion of future directions of research in this field.
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U2 - 10.1039/c7an01442b
DO - 10.1039/c7an01442b
M3 - Review article
C2 - 29106427
AN - SCOPUS:85034733348
VL - 142
SP - 4343
EP - 4354
JO - Analyst
JF - Analyst
SN - 0003-2654
IS - 23
ER -