Microfluidic model of the outer blood-retina-barrier

Li Jiun Chen, Shun Ito, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A microfluidic outer blood-retina-barrier model (oBRB) is developed and used to investigate known inflammatory factors (hyperglycemia and hypoxia) on retinal epithelial cell (RPE)-choroid interactions. RPE cells and the vasculature were evaluated independently before culturing altogether. Morphology of vasculature as a result of different interventions was observed although more work is required to quantify and to perform statistical tests to conclude the results. Unlike the existing oBRB-vasculature models where vasculature development is the main focus, our device allows examining barrier integrity of the RPE, along with dynamic interactions between the RPE and the vasculature.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1575-1578
Number of pages4
ISBN (Electronic)9781510897571
Publication statusPublished - 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

Keywords

  • Blood-retina-barrier
  • Interactions
  • Microfluidic
  • Microvessel
  • Transepithelial electrical resistance

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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