Microfluidic chip having multi fluorescence microsensors for spatiotemporal sensing of culture environment

Hisataka Maruyama, Keisuke Takagi, Taisuke Masuda, Osamu Suzuki, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We proposed on-chip spatiotemporal sensing for monitoring interactions between cells and environment using fluorescence multi-microsensors. The microfluidic chip integrating fluorescence multi-microsensor is used to construct the harmonious environment like in vivo to reconstruct high-quality organs ex vivo. Fluorescence sensing is suitable for spatiotemporal sensing with high spatial resolution because wiring to many microsensors limits the number of sensors. First, we classify optical sensing method. Fluorescence and polarization sensing are suitable for spatiotemporal sensing such as physiological and mechanical parameters in culture environment. As a demonstration of spatiotemporal sensing of culture environment, Spatiotemporal variation of pH, Ca2+ was measured and during transformation of octacalcium phosphate (OCP) to hydroxyl apatite (HA) inside the microfluidic chip using fluorescence multi-microsensors.

Original languageEnglish
Title of host publication2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages386-389
Number of pages4
ISBN (Electronic)9781509050789
DOIs
Publication statusPublished - 2017 Feb 23
Event30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States
Duration: 2017 Jan 222017 Jan 26

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
CountryUnited States
CityLas Vegas
Period17/1/2217/1/26

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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