TY - CHAP
T1 - Microfabrication and Nanofabrication Techniques
AU - Ahadian, Samad
AU - Ostrovidov, Serge
AU - Fujie, Toshinori
AU - Parthiban, Selvakumar Prakash
AU - Kaji, Hirokazu
AU - Sampathkumar, Kaarunya
AU - Ramalingam, Murugan
AU - Khademhosseini, Ali
N1 - Funding Information:
We apologize to our colleagues whose work could not be cited and discussed due to space limitations. This research was supported by the World Premier International Research Center Initiative (WPI), MEXT, Japan.
Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - The aim of dental tissue engineering (TE) is to repair or regenerate dental tissues with the help of biomaterials, scaffolds, growth factors, and dental cells. Tooth regeneration involves the exchange of complicated signals between mesenchymal and epithelial cells in a well-defined structural and compositional milieu to regulate the different stages of tooth development. In this light, micro- and nanofabrication techniques are powerful tools that spatially pattern cells in a controlled and predefined structure, regulating the cellular microenvironment, cell fate, and tissue formation to mimic natural tooth formation. Here, we delineate the basic principles and applications of micro- and nanoscale technologies to study dental cells and to regenerate the tooth. In particular, these technologies have been used to construct both cell-free and cell-laden scaffolds, to direct stem cell fate, and to elucidate stem cell biology. We conclude this chapter by outlining the major challenges to and future directions of engineering dental tissues with the aid of micro- and nanofabrication techniques.
AB - The aim of dental tissue engineering (TE) is to repair or regenerate dental tissues with the help of biomaterials, scaffolds, growth factors, and dental cells. Tooth regeneration involves the exchange of complicated signals between mesenchymal and epithelial cells in a well-defined structural and compositional milieu to regulate the different stages of tooth development. In this light, micro- and nanofabrication techniques are powerful tools that spatially pattern cells in a controlled and predefined structure, regulating the cellular microenvironment, cell fate, and tissue formation to mimic natural tooth formation. Here, we delineate the basic principles and applications of micro- and nanoscale technologies to study dental cells and to regenerate the tooth. In particular, these technologies have been used to construct both cell-free and cell-laden scaffolds, to direct stem cell fate, and to elucidate stem cell biology. We conclude this chapter by outlining the major challenges to and future directions of engineering dental tissues with the aid of micro- and nanofabrication techniques.
KW - Dental stem cell biology
KW - Dental tissue engineering
KW - Microfabrication
KW - Nanofabrication
KW - Scaffolds
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U2 - 10.1016/B978-0-12-397157-9.00017-5
DO - 10.1016/B978-0-12-397157-9.00017-5
M3 - Chapter
AN - SCOPUS:84942774912
SN - 9780123971579
SP - 207
EP - 219
BT - Stem Cell Biology and Tissue Engineering in Dental Sciences
PB - Elsevier Inc.
ER -