Microfabrication and Nanofabrication Techniques

Samad Ahadian, Serge Ostrovidov, Toshinori Fujie, Selvakumar Prakash Parthiban, Hirokazu Kaji, Kaarunya Sampathkumar, Murugan Ramalingam, Ali Khademhosseini

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


The aim of dental tissue engineering (TE) is to repair or regenerate dental tissues with the help of biomaterials, scaffolds, growth factors, and dental cells. Tooth regeneration involves the exchange of complicated signals between mesenchymal and epithelial cells in a well-defined structural and compositional milieu to regulate the different stages of tooth development. In this light, micro- and nanofabrication techniques are powerful tools that spatially pattern cells in a controlled and predefined structure, regulating the cellular microenvironment, cell fate, and tissue formation to mimic natural tooth formation. Here, we delineate the basic principles and applications of micro- and nanoscale technologies to study dental cells and to regenerate the tooth. In particular, these technologies have been used to construct both cell-free and cell-laden scaffolds, to direct stem cell fate, and to elucidate stem cell biology. We conclude this chapter by outlining the major challenges to and future directions of engineering dental tissues with the aid of micro- and nanofabrication techniques.

Original languageEnglish
Title of host publicationStem Cell Biology and Tissue Engineering in Dental Sciences
PublisherElsevier Inc.
Number of pages13
ISBN (Electronic)9780123977786
ISBN (Print)9780123971579
Publication statusPublished - 2015


  • Dental stem cell biology
  • Dental tissue engineering
  • Microfabrication
  • Nanofabrication
  • Scaffolds

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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