Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens

Hajime Miyaguchi; Manabu Tokeshi; Yoshikuni Kikutani; Akihide Hibara; Hiroyuki Inoue; Takehiko Kitamori

Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens

Hajime Miyaguchi, Manabu Tokeshi, Yoshikuni Kikutani, Akihide Hibara, Hiroyuki Inoue, Takehiko Kitamori

Research output: Contribution to conference › Paper › peer-review

Abstract

As the first application of pressure-driven microfluidics in forensic toxicology, a microchip-based liquid-liquid extraction for the gas-chromatography assay for amphetamine-type stimulants in urine has been developed. The interface consisting of 1-chlorobutane and alkalized urine was stabilized in the asymmetric microchannel modified partially with the capillarity restricted modification (CARM) method. As a practical demonstration, methoxyphenamine hydrochloride was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined.

Original language	English
Pages	936-938
Number of pages	3
Publication status	Published - 2006
Externally published	Yes
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 2006 Nov 5 → 2006 Nov 9

Other

Other	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country	Japan
City	Tokyo
Period	06/11/5 → 06/11/9

Keywords

Amphetamines
Forensic toxicology
Solvent extraction

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

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Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens. / Miyaguchi, Hajime; Tokeshi, Manabu; Kikutani, Yoshikuni; Hibara, Akihide; Inoue, Hiroyuki; Kitamori, Takehiko.

2006. 936-938 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Contribution to conference › Paper › peer-review

Miyaguchi, Hajime ; Tokeshi, Manabu ; Kikutani, Yoshikuni ; Hibara, Akihide ; Inoue, Hiroyuki ; Kitamori, Takehiko. / Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.3 p.

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abstract = "As the first application of pressure-driven microfluidics in forensic toxicology, a microchip-based liquid-liquid extraction for the gas-chromatography assay for amphetamine-type stimulants in urine has been developed. The interface consisting of 1-chlorobutane and alkalized urine was stabilized in the asymmetric microchannel modified partially with the capillarity restricted modification (CARM) method. As a practical demonstration, methoxyphenamine hydrochloride was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined.",

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AU - Miyaguchi, Hajime

AU - Tokeshi, Manabu

AU - Kikutani, Yoshikuni

AU - Hibara, Akihide

AU - Inoue, Hiroyuki

AU - Kitamori, Takehiko

PY - 2006

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AB - As the first application of pressure-driven microfluidics in forensic toxicology, a microchip-based liquid-liquid extraction for the gas-chromatography assay for amphetamine-type stimulants in urine has been developed. The interface consisting of 1-chlorobutane and alkalized urine was stabilized in the asymmetric microchannel modified partially with the capillarity restricted modification (CARM) method. As a practical demonstration, methoxyphenamine hydrochloride was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined.

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KW - Forensic toxicology

KW - Solvent extraction

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