Abstract
As the first application of pressure-driven microfluidics in forensic toxicology, a microchip-based liquid-liquid extraction for the gas-chromatography assay for amphetamine-type stimulants in urine has been developed. The interface consisting of 1-chlorobutane and alkalized urine was stabilized in the asymmetric microchannel modified partially with the capillarity restricted modification (CARM) method. As a practical demonstration, methoxyphenamine hydrochloride was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined.
| Original language | English |
|---|---|
| Pages | 936-938 |
| Number of pages | 3 |
| Publication status | Published - 2006 Jan 1 |
| Externally published | Yes |
| Event | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 2006 Nov 5 → 2006 Nov 9 |
Other
| Other | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 |
|---|---|
| Country | Japan |
| City | Tokyo |
| Period | 06/11/5 → 06/11/9 |
Keywords
- Amphetamines
- Forensic toxicology
- Solvent extraction
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering
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Cite this
Miyaguchi, H., Tokeshi, M., Kikutani, Y., Hibara, A., Inoue, H., & Kitamori, T. (2006). Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens. 936-938. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.