Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens

Hajime Miyaguchi, Manabu Tokeshi, Yoshikuni Kikutani, Akihide Hibara, Hiroyuki Inoue, Takehiko Kitamori

Research output: Contribution to conferencePaper

Abstract

As the first application of pressure-driven microfluidics in forensic toxicology, a microchip-based liquid-liquid extraction for the gas-chromatography assay for amphetamine-type stimulants in urine has been developed. The interface consisting of 1-chlorobutane and alkalized urine was stabilized in the asymmetric microchannel modified partially with the capillarity restricted modification (CARM) method. As a practical demonstration, methoxyphenamine hydrochloride was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined.

Original languageEnglish
Pages936-938
Number of pages3
Publication statusPublished - 2006 Jan 1
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 2006 Nov 52006 Nov 9

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period06/11/506/11/9

Keywords

  • Amphetamines
  • Forensic toxicology
  • Solvent extraction

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Miyaguchi, H., Tokeshi, M., Kikutani, Y., Hibara, A., Inoue, H., & Kitamori, T. (2006). Microchip-based rapid sample-preparation for gas-chromatography assay of amphetamine-type stimulants in urine specimens. 936-938. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.