TY - JOUR
T1 - Microchip-based chemical and biochemical analysis systems
AU - Sato, Kiichi
AU - Hibara, Akihide
AU - Tokeshi, Manabu
AU - Hisamoto, Hideaki
AU - Kitamori, Takehiko
N1 - Funding Information:
We want to thank members of the Kitamori Laboratory (University of Tokyo), Integrated Chemistry Project (KAST), and Institute of Microchemical Technology. This work was partially supported by the Ministry of Education, Science, Sports, Culture and Technology of Japan.
PY - 2003/2/24
Y1 - 2003/2/24
N2 - This review focuses on chemical and biochemical analysis systems using pressure-driven microfluidic devices or microchips. Liquid microspace in a microchip has several characteristic features, for example, short diffusion distances, high specific interfacial area and small heat capacity. These characteristics are the key to controlling micro unit operations and constructing new integrated chemical systems. By combining multiphase laminar flow and the micro unit operations, such as mixing, reaction, extraction and separation, continuous flow chemical processing systems are realized in the microchip format. By applying these concepts, several different analysis systems were successfully integrated on a microchip. In this paper, we introduce the microchip-based chemical systems for wet analysis of cobalt ion, multi-ion sensors, immunoassay, and cellular analysis.
AB - This review focuses on chemical and biochemical analysis systems using pressure-driven microfluidic devices or microchips. Liquid microspace in a microchip has several characteristic features, for example, short diffusion distances, high specific interfacial area and small heat capacity. These characteristics are the key to controlling micro unit operations and constructing new integrated chemical systems. By combining multiphase laminar flow and the micro unit operations, such as mixing, reaction, extraction and separation, continuous flow chemical processing systems are realized in the microchip format. By applying these concepts, several different analysis systems were successfully integrated on a microchip. In this paper, we introduce the microchip-based chemical systems for wet analysis of cobalt ion, multi-ion sensors, immunoassay, and cellular analysis.
KW - Continuous flow chemical processing
KW - Integrated chemistry lab
KW - Labs-on-a-chip
KW - Micro unit operation
KW - Microfluidic device
KW - Multiphase laminar flow
KW - Thermal lens microscope
KW - μ-TAS
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U2 - 10.1016/S0169-409X(02)00225-9
DO - 10.1016/S0169-409X(02)00225-9
M3 - Review article
C2 - 12628322
AN - SCOPUS:0037462996
VL - 55
SP - 379
EP - 391
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 3
ER -