Microchannel device using self-spreading lipid bilayer as molecule carrier

Kazuaki Furukawa, Hiroshi Nakashima, Yoshiaki Kashimura, Keiichi Torimitsu

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

We propose a microchannel device that employs a surface-supported self-spreading lipid bilayer membrane as a molecule carrying medium. The device has a micropattern structure fabricated on a SiO2 surface by photolithography, into which a self-spreading lipid bilayer membrane is introduced as the carrier medium. This system corresponds to a microchannel with a single lipid bilayer membrane height of ∼5 nm, compared with conventional micro-fluidic channels that have a section height and width of at least several μm. The device is beneficial for detecting intermolecular interactions when molecules carried by the self-spreading lipid bilayer collide with each other in the microchannel. The validity of the device was confirmed by observing the fluorescence resonance energy transfer (FRET) between two dye molecules, coumarin and fluorescein.

Original languageEnglish
Pages (from-to)1001-1006
Number of pages6
JournalLab on a Chip
Volume6
Issue number8
DOIs
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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