TY - JOUR
T1 - Microchannel-assisted thermal-lens spectrometry for microchip analysis
AU - Tamaki, Eiichiro
AU - Hibara, Akihide
AU - Tokeshi, Manabu
AU - Kitamori, Takehiko
N1 - Funding Information:
This research was partially supported by Asahi Kasei Corporation, Shimadzu Science Foundation and by the Ministry of Education, Science, Sports, Culture and Technology of Japan, Grant-in-Aid for Encouragement of Young Scientists, 12750712, 2000, and Grant-in-Aid for Scientific Research for University and Social Collaboration, 11974006, 1999.
PY - 2003/2/14
Y1 - 2003/2/14
N2 - Microchannel-assisted thermal lens spectrometry (MATLS) was developed for microchip analysis. This method utilized a photothermal effect in a very small space and rapid thermal conduction between a solid-liquid interface to produce a temperature gradient in the microchannel. In order to examine the mechanism experimentally, we constructed a detection system of laser defocus setup in which an excitation beam was not tightly focused, but it irradiated the microchannel homogeneously. The signal intensity dependence on modulation frequency of excitation and on solvent was investigated with the laser defocusing setup. The results of this investigation indicated that the mechanism of MATLS worked as expected. Since the mechanism of MATLS does not require directivity and coherence of the laser beam, other incoherent light sources can be used as excitation light for sensitive detections. Finally, we considered some future applications utilizing the mechanism.
AB - Microchannel-assisted thermal lens spectrometry (MATLS) was developed for microchip analysis. This method utilized a photothermal effect in a very small space and rapid thermal conduction between a solid-liquid interface to produce a temperature gradient in the microchannel. In order to examine the mechanism experimentally, we constructed a detection system of laser defocus setup in which an excitation beam was not tightly focused, but it irradiated the microchannel homogeneously. The signal intensity dependence on modulation frequency of excitation and on solvent was investigated with the laser defocusing setup. The results of this investigation indicated that the mechanism of MATLS worked as expected. Since the mechanism of MATLS does not require directivity and coherence of the laser beam, other incoherent light sources can be used as excitation light for sensitive detections. Finally, we considered some future applications utilizing the mechanism.
KW - Chip technology
KW - Instrumentation
KW - Thermal lens spectrometry
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U2 - 10.1016/S0021-9673(02)01661-8
DO - 10.1016/S0021-9673(02)01661-8
M3 - Article
C2 - 12613812
AN - SCOPUS:0037435956
VL - 987
SP - 197
EP - 204
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
IS - 1-2
ER -