Micro-phase-contrast X-ray computed tomography for basic biomëdical research in SPrine-8

Jin Wu, Tbhoru Takeda, Thet Thet Lwin, Ichiro Koyama, Atsushi Momose, Akiko Fujii, Yoshitaka Hamaishi, Taichi Kuroe, Tetsuya Yuasa, Yoshio Suzuki, Takao Akatsuka

Research output: Contribution to journalConference articlepeer-review

7 Citations (Scopus)

Abstract

Micro-phase-contrast X-ray computed tomography with an X-ray interferometer (micro-phase-contrast CT) is in operation to obtain high spatial resolution images of less than 0.01 mm at the undulator beam-line 20XU of SPring-8, Japan, and we applied micro-phase-contrast CT to observe the organs of rats and hamsters. The excised kidney and spleen fixed by formalin were imaged. The fine inner-structures such as vessels, glomeruli of kidney and white and red pulps of spleen were visualized clearly about 0.01-mm spatial resolutions without using contrast agent or staining procedure. The results were very similar to those by optical microscopic images with 20-fold magnification. These results suggest that the micro-phase tomography might be a useful tool for various biomedical researches.

Original languageEnglish
Article number85
Pages (from-to)740-747
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5535
DOIs
Publication statusPublished - 2004 Dec 1
Externally publishedYes
EventDevelopments in X-Ray Tomography IV - Denver, CO, United States
Duration: 2004 Aug 42004 Aug 6

Keywords

  • 3D medical image
  • Biomedical object
  • Interferometer
  • Micro-phase-contrast X-ray CT
  • Synchrotron radiation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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