Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

R. L. Schnaar, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, S. Aizawa

Research output: Contribution to journalReview article

Abstract

Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalChemtracts
Volume11
Issue number3
Publication statusPublished - 1998 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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  • Cite this

    Schnaar, R. L., Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., Fukumoto, S., Haraguchi, M., Takeda, N., Fujimura, K., Sakae, M., Kishikawa, M., Shiku, H., Furukawa, K., & Aizawa, S. (1998). Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Chemtracts, 11(3), 195-200.