Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest

Fumihiro Fujimori, Katsuhiko Takahashi, Chiyoko Uchida, Takafumi Uchida

Research output: Contribution to journalArticlepeer-review

179 Citations (Scopus)

Abstract

The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Although the embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient in their ability to restart proliferation in response to serum stimulation after G0 arrest. These results suggest that Pin1 is required for cell cycle progression from G0 arrest as well as mitosis progression in normal mammalian cells.

Original languageEnglish
Pages (from-to)658-663
Number of pages6
JournalBiochemical and biophysical research communications
Volume265
Issue number3
DOIs
Publication statusPublished - 1999 Nov 30

Keywords

  • Cell cycle
  • Ess1
  • KO mouse
  • PPIase
  • Pin1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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