Abstract
tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob-/- mice than in wild-type mice. tob-/-p53-/- mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase. Levels of tob mRNA are often decreased in human cancers, implicating tob in cancer development.
Original language | English |
---|---|
Pages (from-to) | 1201-1206 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 17 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2003 May 15 |
Externally published | Yes |
Keywords
- Corepressor
- Liver cancer
- Tob
- cyclin D1 expression
ASJC Scopus subject areas
- Genetics
- Developmental Biology