Mice lacking a transcriptional corepressor Tob are predisposed to cancer

Yutaka Yoshida; Takahisa Nakamura; Masato Komoda; Hitoshi Satoh; Toru Suzuki; Junko K. Tsuzuku; Takashi Miyasaka; Eri H. Yoshida; Hisashi Umemori; Reiko K. Kunisaki; Kenzaburo Tani; Shunsuke Ishii; Shigeo Mori; Masami Suganuma; Tetsuo Noda; Tadashi Yamamoto

doi:10.1101/gad.1088003

Mice lacking a transcriptional corepressor Tob are predisposed to cancer

Yutaka Yoshida, Takahisa Nakamura, Masato Komoda, Hitoshi Satoh, Toru Suzuki, Junko K. Tsuzuku, Takashi Miyasaka, Eri H. Yoshida, Hisashi Umemori, Reiko K. Kunisaki, Kenzaburo Tani, Shunsuke Ishii, Shigeo Mori, Masami Suganuma, Tetsuo Noda, Tadashi Yamamoto

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob^-/- mice than in wild-type mice. tob^-/-p53^-/- mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase. Levels of tob mRNA are often decreased in human cancers, implicating tob in cancer development.

Original language	English
Pages (from-to)	1201-1206
Number of pages	6
Journal	Genes and Development
Volume	17
Issue number	10
DOIs	https://doi.org/10.1101/gad.1088003
Publication status	Published - 2003 May 15

Keywords

Corepressor
Liver cancer
Tob
cyclin D1 expression

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1088003

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Mice lacking a transcriptional corepressor Tob are predisposed to cancer. / Yoshida, Yutaka; Nakamura, Takahisa; Komoda, Masato; Satoh, Hitoshi; Suzuki, Toru; Tsuzuku, Junko K.; Miyasaka, Takashi; Yoshida, Eri H.; Umemori, Hisashi; Kunisaki, Reiko K.; Tani, Kenzaburo; Ishii, Shunsuke; Mori, Shigeo; Suganuma, Masami; Noda, Tetsuo; Yamamoto, Tadashi.

In: Genes and Development, Vol. 17, No. 10, 15.05.2003, p. 1201-1206.

Research output: Contribution to journal › Article › peer-review

Yoshida, Yutaka ; Nakamura, Takahisa ; Komoda, Masato ; Satoh, Hitoshi ; Suzuki, Toru ; Tsuzuku, Junko K. ; Miyasaka, Takashi ; Yoshida, Eri H. ; Umemori, Hisashi ; Kunisaki, Reiko K. ; Tani, Kenzaburo ; Ishii, Shunsuke ; Mori, Shigeo ; Suganuma, Masami ; Noda, Tetsuo ; Yamamoto, Tadashi. / Mice lacking a transcriptional corepressor Tob are predisposed to cancer. In: Genes and Development. 2003 ; Vol. 17, No. 10. pp. 1201-1206.

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abstract = "tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob-/- mice than in wild-type mice. tob-/-p53-/- mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase. Levels of tob mRNA are often decreased in human cancers, implicating tob in cancer development.",

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AU - Tsuzuku, Junko K.

AU - Miyasaka, Takashi

AU - Yoshida, Eri H.

AU - Umemori, Hisashi

AU - Kunisaki, Reiko K.

AU - Tani, Kenzaburo

AU - Ishii, Shunsuke

AU - Mori, Shigeo

AU - Suganuma, Masami

AU - Noda, Tetsuo

AU - Yamamoto, Tadashi

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