@article{e158de86a3ca42358c2824bfb1633d36,
title = "Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality",
abstract = "In mammals, the small Arf GTPase-activating protein (SMAP) subfamily of Arf GTPase-activating proteins consists of closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes seen in single knockout mice. The present study investigated whether SMAP proteins interact genetically. We report for the first time that simultaneous loss of SMAP1 and SMAP2 promotes apoptosis in the distal region of E7.5 mouse embryos, likely resulting in embryonic lethality. Thus, at least one SMAP gene, either SMAP1 or SMAP2, is required for proper embryogenesis.",
keywords = "Arf GAP, Embryogenesis, Genetic interaction, SMAP1, SMAP2",
author = "Mami Sumiyoshi and Narumi Masuda and Nobuhiro Tanuma and Honami Ogoh and Eri Imai and Mizuki Otsuka and Natsuki Hayakawa and Kinuyo Ohno and Yasuhisa Matsui and Kanae Hara and Risa Gotoh and Mai Suzuki and Shinya Rai and Hirokazu Tanaka and Itaru Matsumura and Hiroshi Shima and Toshio Watanabe",
note = "Funding Information: We sincerely thank Dr. Isao Matsuo (Osaka Medical Center and Research Institute for Maternal and Child Health) for his critical advice. We thank Dr. Shunsuke Kon (Hokkaido University) for his advice on Co-IP experiments. We also thank Dr. Elise Lamar for English editing. This work was supported by JSPS KAKENHI Grant Number 24570159 to Toshio Watanabe, a Nara Women{\textquoteright}s University Intramural Grant for Project Research to Toshio Watanabe, and a Sasakawa Scientific Research Grant from The Japan Science Society to Honami Ogoh. Publisher Copyright: {\textcopyright} 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = sep,
day = "14",
doi = "10.1016/j.febslet.2015.07.050",
language = "English",
volume = "589",
pages = "2754--2762",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "19",
}