Abstract
Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, Dmrt7, was expressed only in testes of adult mice. To determine the role of Dmrt7 in mice, we generated Dmrt7-knockout mice (Dmrt7-/-). Although the Dmrt7-/- showed normal growth, null males were infertile. No sperm was detected in the epididymis of Dmrt7-/- adult males. Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice.
Original language | English |
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Pages (from-to) | 6442-6446 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 580 |
Issue number | 27 |
DOIs | |
Publication status | Published - 2006 Nov 27 |
Keywords
- Dmrt7
- Knockout mouse
- Male infertility
- Spermatogenesis
- Testis
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology