TY - JOUR
T1 - Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice
AU - Lee, Jin Yong
AU - Hwang, Gi Wook
AU - Kim, Min Seok
AU - Takahashi, Tsutomu
AU - Naganuma, Akira
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Expression of the chemokine genes Ccl2, Ccl4, Ccl7, Ccl9, and Ccl12 is increased in cerebellum of mice treated with methylmercury. To investigate the effect of methylmercury on other tissues and organs, levels of chemokine mRNA were investigated in mouse cerebrum, kidney, liver, and spleen. In cerebrum, expression levels of the five chemokines were significantly increased after methylmercury treatment. In kidney, expression levels of Ccl2, Ccl7, Ccl9, and Ccl12, but not Ccl4 were increased. No significant effects were seen on mRNA levels of the chemokines in liver and spleen. Thus, although methylmercury increases the expression levels of multiple chemokines in the brain and kidney, expression of Ccl4 increases only in the brain. Hence, this phenomenon may be involved in methylmercury toxicity specific to the central nervous system.
AB - Expression of the chemokine genes Ccl2, Ccl4, Ccl7, Ccl9, and Ccl12 is increased in cerebellum of mice treated with methylmercury. To investigate the effect of methylmercury on other tissues and organs, levels of chemokine mRNA were investigated in mouse cerebrum, kidney, liver, and spleen. In cerebrum, expression levels of the five chemokines were significantly increased after methylmercury treatment. In kidney, expression levels of Ccl2, Ccl7, Ccl9, and Ccl12, but not Ccl4 were increased. No significant effects were seen on mRNA levels of the chemokines in liver and spleen. Thus, although methylmercury increases the expression levels of multiple chemokines in the brain and kidney, expression of Ccl4 increases only in the brain. Hence, this phenomenon may be involved in methylmercury toxicity specific to the central nervous system.
KW - Brain
KW - CCL4
KW - Chemokine
KW - Methylmercury
KW - Mouse
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U2 - 10.2131/jts.37.1279
DO - 10.2131/jts.37.1279
M3 - Letter
C2 - 23208444
AN - SCOPUS:84870870606
VL - 37
SP - 1279
EP - 1282
JO - Journal of Toxicological Sciences
JF - Journal of Toxicological Sciences
SN - 1880-3989
IS - 6
ER -