Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization

Mio Tsuruoka, Jun Inoue, Eiji Kakazu, Masashi Ninomiya, Tomoaki Iwata, Akitoshi Sano, Atsushi Masamune

Research output: Contribution to journalArticlepeer-review

Abstract

Methotrexate-related lymphoproliferative disorder (MTX-LPD) is known to be a side effect of MTX, but its involvement in the liver has been rarely reported. We herein report a 70-year-old woman with autoimmune hepatitis and rheumatoid arthritis who developed multiple liver tumors. We initially considered that she had developed rapid-growing hepatocellular carcinoma (HCC) in the cirrhotic liver based on imaging tests. A tumor biopsy and transcatheter arterial chemoembolization were thus performed. The tumors were then diagnosed as diffuse large B-cell lymphoma pathologically and considered to be MTX-LPD. This case indicates that MTX-LPD should be considered even in cirrhotic patients with liver tumors resembling HCC.

Original languageEnglish
Pages (from-to)2255-2260
Number of pages6
JournalInternal Medicine
Volume59
Issue number18
DOIs
Publication statusPublished - 2020 Jun

Keywords

  • AIH
  • DLBCL
  • Liver tumor
  • MTX-LPD
  • RA

ASJC Scopus subject areas

  • Internal Medicine

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