Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization

Mio Tsuruoka; Jun Inoue; Eiji Kakazu; Masashi Ninomiya; Tomoaki Iwata; Akitoshi Sano; Atsushi Masamune

doi:10.2169/INTERNALMEDICINE.4787-20

Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization

Mio Tsuruoka, Jun Inoue, Eiji Kakazu, Masashi Ninomiya, Tomoaki Iwata, Akitoshi Sano, Atsushi Masamune

Research output: Contribution to journal › Article › peer-review

Abstract

Methotrexate-related lymphoproliferative disorder (MTX-LPD) is known to be a side effect of MTX, but its involvement in the liver has been rarely reported. We herein report a 70-year-old woman with autoimmune hepatitis and rheumatoid arthritis who developed multiple liver tumors. We initially considered that she had developed rapid-growing hepatocellular carcinoma (HCC) in the cirrhotic liver based on imaging tests. A tumor biopsy and transcatheter arterial chemoembolization were thus performed. The tumors were then diagnosed as diffuse large B-cell lymphoma pathologically and considered to be MTX-LPD. This case indicates that MTX-LPD should be considered even in cirrhotic patients with liver tumors resembling HCC.

Original language	English
Pages (from-to)	2255-2260
Number of pages	6
Journal	Internal Medicine
Volume	59
Issue number	18
DOIs	https://doi.org/10.2169/INTERNALMEDICINE.4787-20
Publication status	Published - 2020 Jun

Keywords

AIH
DLBCL
Liver tumor
MTX-LPD
RA

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/INTERNALMEDICINE.4787-20

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Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization. / Tsuruoka, Mio; Inoue, Jun; Kakazu, Eiji; Ninomiya, Masashi; Iwata, Tomoaki; Sano, Akitoshi; Masamune, Atsushi.

In: Internal Medicine, Vol. 59, No. 18, 06.2020, p. 2255-2260.

Research output: Contribution to journal › Article › peer-review

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title = "Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization",

abstract = "Methotrexate-related lymphoproliferative disorder (MTX-LPD) is known to be a side effect of MTX, but its involvement in the liver has been rarely reported. We herein report a 70-year-old woman with autoimmune hepatitis and rheumatoid arthritis who developed multiple liver tumors. We initially considered that she had developed rapid-growing hepatocellular carcinoma (HCC) in the cirrhotic liver based on imaging tests. A tumor biopsy and transcatheter arterial chemoembolization were thus performed. The tumors were then diagnosed as diffuse large B-cell lymphoma pathologically and considered to be MTX-LPD. This case indicates that MTX-LPD should be considered even in cirrhotic patients with liver tumors resembling HCC.",

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AU - Ninomiya, Masashi

AU - Iwata, Tomoaki

AU - Sano, Akitoshi

AU - Masamune, Atsushi

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AB - Methotrexate-related lymphoproliferative disorder (MTX-LPD) is known to be a side effect of MTX, but its involvement in the liver has been rarely reported. We herein report a 70-year-old woman with autoimmune hepatitis and rheumatoid arthritis who developed multiple liver tumors. We initially considered that she had developed rapid-growing hepatocellular carcinoma (HCC) in the cirrhotic liver based on imaging tests. A tumor biopsy and transcatheter arterial chemoembolization were thus performed. The tumors were then diagnosed as diffuse large B-cell lymphoma pathologically and considered to be MTX-LPD. This case indicates that MTX-LPD should be considered even in cirrhotic patients with liver tumors resembling HCC.

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Methotrexate-associated lymphoproliferative disorder in the liver resembling hepatocellular carcinoma treated with transarterial chemoembolization

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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