Long term creep rupture life is usually evaluated from short term data by a time-temperature parameter (TTP) method. The apparent activation energy Q for rupture life of steels sometimes changes from a high value of short term creep to a low value of long term creep. However, the conventional TTP analyses ignore the decrease in Q, resulting in the overestimation of rupture life recognized recently in advanced high Cr ferritic steels. A multi region analysis of creep rupture data is applied to a creep data set of Gr. 122 steel; in the analysis a creep rupture data is divided into several data sets so that Q value is unique in each divided data set. The multi region analysis provides the best fit to the data and the lowest value of 105 h creep rupture strength among the three ways of data analysis examined. The conventional single region analysis cannot correctly represent the data points and predicts the highest strength. A half of 0.2 % proof stress could not be an appropriate boundary for dividing data to be used in the multi region analysis. In the 2001 Edition of ASME Code an F average concept has been proposed as a substitution for the safety factor of 2/3 for average rupture stress. The allowable stress of Gr. 122 steel may decrease significantly when the F average concept and the multi region analysis are adopted.