Methionine-enkephalin-Arg6-Gly7-Leu8-immunoreactive nerve fibers and cell bodies in lumbar paravertebral ganglia and the celiac-superior mesenteric ganglion complex of the rat: An immunohistochemical study

Tooru Shimosegawa, Masaru Koizumi, Takayoshi Toyota, Yoshio Goto, Shigeru Kobayashi, Chizuko Yanaihara, Noboru Yanaihara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Lumbar paravertebral ganglia and prevertebral ganglia of the rat were immunohistochemically examined using an antiserum against Methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu). Colchicine (5 mg/kg body wt., i.p. injection) was employed as an axonal transport blocker to intensify the immunoreactivity in the nerve cell bodies. In the lumbar paravertebral ganglia of the colchicine-treated rats, about 55% of nerve cell bodies showed a positive immunoreactivity. In the celiac-superior mesenteric ganglion complex, a dense network of positively immunostained nerve fiber varicosities surrounded immunonegative nerve cell bodies. The Met-Enk-Arg-Gly-Leu-like immunoreactivity demonstrated in this study suggests the occurrence of preproenkephalin A and related opioid peptides.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalNeuroscience Letters
Volume57
Issue number2
DOIs
Publication statusPublished - 1985 Jun 12

Keywords

  • celiac-superior mesenteric ganglion complex
  • colchicine
  • immunohistochemistry
  • lumbar paravertebral ganglion
  • methionine-enkephalin-Arg-Gly-Leu
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Methionine-enkephalin-Arg<sup>6</sup>-Gly<sup>7</sup>-Leu<sup>8</sup>-immunoreactive nerve fibers and cell bodies in lumbar paravertebral ganglia and the celiac-superior mesenteric ganglion complex of the rat: An immunohistochemical study'. Together they form a unique fingerprint.

  • Cite this