Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus

Yohei Kera, Yasutake Katoh, Mineto Ohta, Mitsuyo Matsumoto, Teruko Takano-Yamamoto, Kazuhiko Igarashi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: MATII biosynthesizes AdoMet, which supplies methyl group for methylation of molecules, including histone. Results: MATII interacts with histone methyltransferase SETDB1 and inhibits COX-2 gene expression. Conclusion: AdoMet synthesis and histone methylation are coupled on chromatin by a physical interaction of MATII and SETDB1 at the MafK target genes. Significance: MATII may be important for both gene-specific and epigenome-wide regulation of histone methylation.

Original languageEnglish
Pages (from-to)13592-13601
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
Publication statusPublished - 2013 May 10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus'. Together they form a unique fingerprint.

  • Cite this