Metallothionein-mediated resistance to multiple drugs can be induced by several anticancer drugs in mice

Yoichi Okazaki, Nobuhiko Miura, Masahiko Satoh, Nobumasa Imura, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

We examined the role of metallothionein in the chemosensitivity of transplanted tumors in mice. The antitumor activities of cisplatin, adriamycin, bleomycin, peplomycin, cyclophosphamide, and melphalan were significantly suppressed when the concentration of metallothionein in the tumor was increased to only twice the control level. On the other hand, the antitumor activities of mitomycin C, 5-fluorouracil, and vinblastine were hardly affected by increases in the concentration of metallothionein in the tumors in mice. Moreover, all the antitumor drugs examined increased the concentration of metallothionein in transplanted tumors to a level that was high enough to suppress the antitumor activity of these drugs. These observations suggest that treatment of patients with certain antitumor drugs might result in the resistance of their tumors to multiple drugs.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalBiochemical and biophysical research communications
Volume245
Issue number3
DOIs
Publication statusPublished - 1998 Apr 28

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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