TY - JOUR
T1 - Metallothionein-mediated resistance to multiple drugs can be induced by several anticancer drugs in mice
AU - Okazaki, Yoichi
AU - Miura, Nobuhiko
AU - Satoh, Masahiko
AU - Imura, Nobumasa
AU - Naganuma, Akira
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, Sports, and Culture of Japan and by a Grant-in-Aid from the Tokyo Biochemical Research Foundation.
PY - 1998/4/28
Y1 - 1998/4/28
N2 - We examined the role of metallothionein in the chemosensitivity of transplanted tumors in mice. The antitumor activities of cisplatin, adriamycin, bleomycin, peplomycin, cyclophosphamide, and melphalan were significantly suppressed when the concentration of metallothionein in the tumor was increased to only twice the control level. On the other hand, the antitumor activities of mitomycin C, 5-fluorouracil, and vinblastine were hardly affected by increases in the concentration of metallothionein in the tumors in mice. Moreover, all the antitumor drugs examined increased the concentration of metallothionein in transplanted tumors to a level that was high enough to suppress the antitumor activity of these drugs. These observations suggest that treatment of patients with certain antitumor drugs might result in the resistance of their tumors to multiple drugs.
AB - We examined the role of metallothionein in the chemosensitivity of transplanted tumors in mice. The antitumor activities of cisplatin, adriamycin, bleomycin, peplomycin, cyclophosphamide, and melphalan were significantly suppressed when the concentration of metallothionein in the tumor was increased to only twice the control level. On the other hand, the antitumor activities of mitomycin C, 5-fluorouracil, and vinblastine were hardly affected by increases in the concentration of metallothionein in the tumors in mice. Moreover, all the antitumor drugs examined increased the concentration of metallothionein in transplanted tumors to a level that was high enough to suppress the antitumor activity of these drugs. These observations suggest that treatment of patients with certain antitumor drugs might result in the resistance of their tumors to multiple drugs.
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U2 - 10.1006/bbrc.1998.8509
DO - 10.1006/bbrc.1998.8509
M3 - Article
C2 - 9588197
AN - SCOPUS:0032576985
VL - 245
SP - 815
EP - 818
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -