Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination

Masahiko Satoh, Akira Naganuma, Nobumasa Imura

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The protective effects of metallothionein (MT) preinduction by bismuth subnitrate (BSN) against the renal toxicity of cis-diamminedichloroplatinum (cis-DDP), the cardiotoxicity of adriamycin (ADR), and the lethal and bone marrow toxicities of these drugs were observed in mice receiving cis-DDP and ADR simultaneously. Preinduction of MT biosynthesis by BSN, which is currently used as an antidiarrheal drug, did not affect the antitumor activities of the two drugs, suggesting that the beneficial effects of the preinduction of MT biosynthesis by BSN may be applicable for therapy involving cis-DDP and ADR, either alone or in combination.

Original languageEnglish
Pages (from-to)176-178
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume21
Issue number2
DOIs
Publication statusPublished - 1988 Apr 1

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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