Metallic glass nanofibers in future hydrogel-based scaffolds

Ramin B anan Sadeghian, Samad Ahadian, Shin Yaginuma, Javier Ramón-Azcón, Xiaobin Liang, Ken Nakajima, Hitoshi Shiku, Tomokazu Matsue, Koji S. Nakayama, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

Abstract

Electrically conductive reinforced hydrogels offer a wide range of applications as three-dimensional scaffolds in tissue engineering. We report electrical and mechanical characterization of methacrylated gelatin (GelMA) hydrogel, containing palladium-based metallic glass nanofibers (MGNF). Also we show that the fibers are biocompatible and C2C12 myoblasts in particular, planted into the hybrid hydrogel, tend to attach to and elongate along the fibers. The MGNFs in this work were created by gas atomization. Ravel of fibers were embedded in the GelMA prepolymer in two different concentrations (0.5 and 1.0 mg/ml), and then the ensemble was cured under UV light, forming the hybrid hydrogel. The conductivity of the hybrid hydrogel was proportional to the fiber concentration.

ASJC Scopus subject areas

  • Medicine(all)

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