Metallic biomaterials

Mitsuo Niinomi

Research output: Contribution to journalReview articlepeer-review

216 Citations (Scopus)


Ti alloys composed of nontoxic and allergy-free elements and Ni-free stainless steels and Co-Cr alloys are currently being developed. Ni-free Ti alloys exhibiting superelastic behavior, or the shape memory effect, are also being developed. β-type Ti alloy with a low elastic modulus has proved to be effective for inhibiting bone absorption and enhancing bone remodeling. Simple bioactive surface modifications such as alkali-treatment processes and the calcium phosphate glass-ceramic dip-coating method are applicable to newly developed β-type Ti alloys such as lowmodulus Ti-29Nb-13Ta-4.6Zr. Blood-compatible polymers such as poly(ethylene glycol) have been successfully fixed on the surface of Ti via chemical bonding by an electrodeposition method. Ti alloys for dental applications have also been recently developed.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalJournal of Artificial Organs
Issue number3
Publication statusPublished - 2008 Sep 1


  • Bioactive surface modification
  • Dental titanium alloy
  • Low modulus
  • Metallic biomaterials
  • Shape memory effect
  • Superelasticity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine


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