Metal-free chiral phosphoric acid or chiral metal phosphate as active catalyst in the activation of N -acyl aldimines

Masahiro Terada, Kyohei Kanomata

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Whether metal-free chiral phosphoric acid or chiral metal phosphate functions as an active catalyst was confirmed in three reactions. In the aza-Friedel-Crafts and aza-ene-type reactions, a metal-free chiral phosphoric acid, namely, a chiral Bronsted acid, was verified to be the active catalyst. In contrast, the substitution reaction of -diazoacetate with aldimine was accelerated by a salt-containing chiral phosphoric acid and hence chiral metal phosphate presumably functioned as an active catalyst.

Original languageEnglish
Article numberY03811ST
Pages (from-to)1255-1258
Number of pages4
JournalSynlett
Issue number9
DOIs
Publication statusPublished - 2011 May 2

Keywords

  • Friedel-Crafts reaction
  • asymmetric catalysis
  • enantioselectivity
  • organocatalysis
  • substitution

ASJC Scopus subject areas

  • Organic Chemistry

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