Abstract
The influences of the lack of metallothionein (MT)-I and MT-II on mercury accumulation in the brain and the changes of zinc and copper concentrations and metal components of MTs were examined after mercury vapor exposure by using MT-I, II null mice and 129/Sv mice as experimental animals. Metal components of metal-binding proteins of soluble fractions in the brain sections were analyzed by high-performance liquid chromatography (HPLC) connected with inductively coupled plasma mass spectrometry (ICP-MS). The Hg levels of MT-I, II null mice in each brain section were significantly higher than those of wild-type mice after mercury vapor exposure. It was suggested that MT-III is associated with the storage of mercury in conditions lacking MT-I and MT-II.
Original language | English |
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Pages (from-to) | 1514-1519 |
Number of pages | 6 |
Journal | Analytical and Bioanalytical Chemistry |
Volume | 381 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2005 Apr |
Keywords
- Brain
- Copper
- ICP-MS
- Mercury vapor
- Metallothionein
- Zinc
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry