Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug

Tomoko Fukuuchi, Katsumi Doh-ura, Shin'ichi Yoshihara, Shigeru Ohta

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.

Original languageEnglish
Pages (from-to)5982-5987
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number23
DOIs
Publication statusPublished - 2006 Dec 1

Keywords

  • 2,2′-Biquinoline
  • Chelate
  • Cimetidine
  • Copper
  • Metal complex
  • Prion
  • SOD activity
  • TPEN

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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