Abstract
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
Original language | English |
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Article number | 115233 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2020 Jan 15 |
Externally published | Yes |
Keywords
- Cell-cycle
- Marine sponge
- Structure elucidation
- Terpenoid
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry