Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression

Yuki Hitora; Kentaro Takada; Yuji Ise; Sau Pinn Woo; Seiya Inoue; Naoki Mori; Hirosato Takikawa; Shohei Nakamukai; Shigeru Okada; Shigeki Matsunaga

doi:10.1016/j.bmc.2019.115233

Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression

Yuki Hitora, Kentaro Takada, Yuji Ise, Sau Pinn Woo, Seiya Inoue, Naoki Mori, Hirosato Takikawa, Shohei Nakamukai, Shigeru Okada, Shigeki Matsunaga

Research output: Contribution to journal › Article

Abstract

New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.

Original language	English
Article number	115233
Journal	Bioorganic and Medicinal Chemistry
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.bmc.2019.115233
Publication status	Published - 2020 Jan 15
Externally published	Yes

Keywords

Cell-cycle
Marine sponge
Structure elucidation
Terpenoid

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Hitora, Y., Takada, K., Ise, Y., Woo, S. P., Inoue, S., Mori, N., Takikawa, H., Nakamukai, S., Okada, S., & Matsunaga, S. (2020). Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression. Bioorganic and Medicinal Chemistry, 28(2), [115233]. https://doi.org/10.1016/j.bmc.2019.115233

Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression. / Hitora, Yuki; Takada, Kentaro; Ise, Yuji; Woo, Sau Pinn; Inoue, Seiya; Mori, Naoki; Takikawa, Hirosato; Nakamukai, Shohei; Okada, Shigeru; Matsunaga, Shigeki.

In: Bioorganic and Medicinal Chemistry, Vol. 28, No. 2, 115233, 15.01.2020.

Research output: Contribution to journal › Article

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