Metabolic interactions between essential and trans-fatty acids

Michihiro Sugano, Ikuo Ikeda

Research output: Contribution to journalShort surveypeer-review

28 Citations (Scopus)


Trans-fatty acids exacerbate essential fatty acid deficiency in experimental animals by interfering with the metabolism of linoleic (18:2n-6) and α-linolenic (18:3n-3) acids and, hence, the eicosanoid production. The interfering effect depends on the type of trans-fatty acid. The detrimental effect of trans-fatty acid, however, apparently disappears when dietary linoleic acid is sufficiently supplemented. Trans-fatty acids appear to disturb fetal growth and birth weight, possibly by the same mechanism.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalCurrent Opinion in Lipidology
Issue number1
Publication statusPublished - 1996 Apr 22
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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