Contractile C2C12 myotube line patterns embedded in a fibrin gel have been developed to afford a physiologically relevant and stable bioassay system. We found that the myotubes supported by an elastic fibrin gel maintained their line patterns and contractile activities for a longer period of time (one week) than myotubes adhered on a conventional culture dish. Now, we are investigating contraction-mediated translocation of the GLUT4 glucose transporter protein in myotubes using this system.
|Title of host publication||Chemical Sensors 9 -and- MEMS/NEMS 9|
|Publisher||Electrochemical Society Inc.|
|Number of pages||5|
|Publication status||Published - 2010|
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