'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates

Naoki Asao; Sunyoung Lee; Yoshinori Yamamoto

doi:10.1016/S0040-4039(03)00891-8

'Me₂CuLi·TMSCl in CH₂Cl₂'. The most powerful methylating agent for sterically congested α,β-enoates

Naoki Asao, Sunyoung Lee, Yoshinori Yamamoto

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The reaction of Me₂CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH₂Cl₂ proceeded very smoothly to produce the conjugate addition products in high yields.

Original language	English
Pages (from-to)	4265-4266
Number of pages	2
Journal	Tetrahedron Letters
Volume	44
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(03)00891-8
Publication status	Published - 2003 May 26

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates",

abstract = "The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.",

author = "Naoki Asao and Sunyoung Lee and Yoshinori Yamamoto",

year = "2003",

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AU - Lee, Sunyoung

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PY - 2003/5/26

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AB - The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.

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JO - Tetrahedron Letters

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SN - 0040-4039

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