'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates

Naoki Asao; Sunyoung Lee; Yoshinori Yamamoto

doi:10.1016/S0040-4039(03)00891-8

'Me₂CuLi·TMSCl in CH₂Cl₂'. The most powerful methylating agent for sterically congested α,β-enoates

Naoki Asao, Sunyoung Lee, Yoshinori Yamamoto

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The reaction of Me₂CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH₂Cl₂ proceeded very smoothly to produce the conjugate addition products in high yields.

Original language	English
Pages (from-to)	4265-4266
Number of pages	2
Journal	Tetrahedron Letters
Volume	44
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(03)00891-8
Publication status	Published - 2003 May 26

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(03)00891-8

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title = "'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates",

abstract = "The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.",

author = "Naoki Asao and Sunyoung Lee and Yoshinori Yamamoto",

year = "2003",

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doi = "10.1016/S0040-4039(03)00891-8",

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T1 - 'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates

AU - Asao, Naoki

AU - Lee, Sunyoung

AU - Yamamoto, Yoshinori

PY - 2003/5/26

Y1 - 2003/5/26

N2 - The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.

AB - The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.

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U2 - 10.1016/S0040-4039(03)00891-8

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EP - 4266

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 22

ER -

'Me₂CuLi·TMSCl in CH₂Cl₂'. The most powerful methylating agent for sterically congested α,β-enoates

Abstract

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