'Me2CuLi·TMSCl in CH2Cl2'. The most powerful methylating agent for sterically congested α,β-enoates

Naoki Asao, Sunyoung Lee, Yoshinori Yamamoto

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    The reaction of Me2CuLi with sterically congested α,β-unsaturated esters in the presence of TMSCl in CH2Cl2 proceeded very smoothly to produce the conjugate addition products in high yields.

    Original languageEnglish
    Pages (from-to)4265-4266
    Number of pages2
    JournalTetrahedron Letters
    Volume44
    Issue number22
    DOIs
    Publication statusPublished - 2003 May 26

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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