Mesoscopic patterning of cell adhesive substrates as novel biofunctional interfaces

Takehiro Nishikawa, Jin Nishida, Ryusuke Ookura, Shin Ichiro Nishimura, Shigeo Wada, Takeshi Karino, Masatsugu Shimomura

    Research output: Contribution to journalArticlepeer-review

    124 Citations (Scopus)


    In this report, cell adhesion to honeycomb-patterned films is described with respect to the dimensions of the honeycomb structure. The honeycomb-patterned films can be fabricated by casting a dilute solution of amphiphilic polymers on solid substrates. The honeycomb structure is not homogeneous in all dimensions. Analysis of distribution of the honeycomb hole sizes demonstrates a gradual decrease in honeycomb hole diameter along the radius of the cast area. The largest holes were located near geometric center of the cast area. The diameter of the largest honeycomb holes in the cast area could be controlled by varying the cast volume of the polymer solution. Cell cultures on the honeycomb films demonstrated that cell adhesion could be inhibited at the outer region of the cast area. The extent of the inhibition of cell adhesion was influenced by the chemical properties of the polymers constituting the honeycomb films.

    Original languageEnglish
    Pages (from-to)141-146
    Number of pages6
    JournalMaterials Science and Engineering C
    Issue number1-2
    Publication statusPublished - 1999 Dec 30


    • Cell adhesion
    • Dimensions of honeycomb structure
    • Honeycomb films

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering


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