Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery

Tatsuya Nakamura, Fuminori Sugihara, Hisashi Matsushita, Yoshichika Yoshioka, Shin Mizukami, Kazuya Kikuchi

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Multifunctional mesoporous silica nanoparticles (MSNs) are good candidates for multimodal applications in drug delivery, bioimaging, and cell targeting. In particular, controlled release of drugs from MSN pores constitutes one of the superior features of MSNs. In this study, a novel drug delivery carrier based on MSNs, which encapsulated highly sensitive 19F magnetic resonance imaging (MRI) contrast agents inside MSNs, was developed. The nanoparticles were labeled with fluorescent dyes and functionalized with small molecule-based ligands for active targeting. This drug delivery system facilitated the monitoring of the biodistribution of the drug carrier by dual modal imaging (NIR/19F MRI). Furthermore, we demonstrated targeted drug delivery and cellular imaging by the conjugation of nanoparticles with folic acid. An anticancer drug (doxorubicin, DOX) was loaded in the pores of folate-functionalized MSNs for intracellular drug delivery. The release rates of DOX from the nanoparticles increased under acidic conditions, and were favorable for controlled drug release to cancer cells. Our results suggested that MSNs may serve as promising 19F MRI-traceable drug carriers for application in cancer therapy and bio-imaging.

Original languageEnglish
Pages (from-to)1986-1990
Number of pages5
JournalChemical Science
Volume6
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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