Mesityllithium as a reagent for chemoselective halogen - lithium exchange reaction

Yoshinori Kondo, Miho Asai, Tohru Miura, Masanobu Uchiyama, Takao Sakamoto

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


(equation presented) Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.

Original languageEnglish
Pages (from-to)13-14
Number of pages2
JournalOrganic letters
Issue number1
Publication statusPublished - 2001 Jan 11

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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