Mesityllithium as a reagent for chemoselective halogen - lithium exchange reaction

Yoshinori Kondo; Miho Asai; Tohru Miura; Masanobu Uchiyama; Takao Sakamoto

doi:10.1021/ol000253x

Mesityllithium as a reagent for chemoselective halogen - lithium exchange reaction

Yoshinori Kondo, Miho Asai, Tohru Miura, Masanobu Uchiyama, Takao Sakamoto

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

(equation presented) Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.

Original language	English
Pages (from-to)	13-14
Number of pages	2
Journal	Organic letters
Volume	3
Issue number	1
DOIs	https://doi.org/10.1021/ol000253x
Publication status	Published - 2001 Jan 11

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "(equation presented) Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.",

author = "Yoshinori Kondo and Miho Asai and Tohru Miura and Masanobu Uchiyama and Takao Sakamoto",

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T1 - Mesityllithium as a reagent for chemoselective halogen - lithium exchange reaction

AU - Kondo, Yoshinori

AU - Asai, Miho

AU - Miura, Tohru

AU - Uchiyama, Masanobu

AU - Sakamoto, Takao

PY - 2001/1/11

Y1 - 2001/1/11

N2 - (equation presented) Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.

AB - (equation presented) Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.

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Mesityllithium as a reagent for chemoselective halogen - lithium exchange reaction

Abstract

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