Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma

Masayuki Tanemoto, Michiaki Abe, Fumitoshi Satoh, Takaaki Abe, Hiroshi Satoh, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of mesangial proliferative glomerulonephritis (MesPGN), the clinical symptoms of which were exacerbated by aldosterone-producing adenoma (APA). A 45-year-old man, who had had a history of hypertension for several years, presented with renal derangement, with serum creatinine at its upper normal limit and with microhematuria and proteinuria. He also presented with hypokalemia, with a plasma aldosterone concentration at its upper normal limit and plasma renin activity at its lower normal limit. After the administration of spironolactone, we resected his left adrenal gland, which had a nodular lesion as well as aldosterone hypersecretion. The treatment normalized his arterial blood pressure and serum potassium concentration. Although his proteinuria disappeared with the reduction in arterial blood pressure, the microhematuria continued. The administration of losartan because of the histological finding of MesPGN reduced the amount of hematuria. A dissociated response of hematuria and proteinuria to antihypertensive treatment indicated that MesPGN was coincidental with APA.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalClinical and experimental nephrology
Volume11
Issue number2
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Aldosterone-producing adenoma
  • Mesangial proliferative glomerulonephritis
  • Primary aldosteronism
  • Renin-angiotensin-aldosterone cascade

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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