Merkel cell carcinoma concomitant with invasive Bowen's disease: Immunohistochemical investigation of tumor-infiltrating leukocytes

Hisayuki Tono, Taku Fujimura, Eimei Iwama, Yoshiyuki Kusakari, Sadanori Furudate, Yumi Kambayashi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba

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1 Citation (Scopus)

Abstract

Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCase Reports in Dermatology
Volume7
Issue number1
DOIs
Publication statusPublished - 2015 May 22

Keywords

  • CD8
  • Caspase 3
  • Invasive Bowen's disease
  • Merkel cell carcinoma
  • Tumor-infiltrating leukocytes

ASJC Scopus subject areas

  • Dermatology

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