MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes

Yoko Miyake; Humika Togashi; Mitsuru Tashiro; Hiroshi Yamaguchi; Shuji Oda; Megumi Kudo; Yoshiyuki Tanaka; Yoshinori Kondo; Ryuichi Sawa; Takashi Fujimoto; Tomoya Machinami; Akira Ono

doi:10.1021/ja056354d

Mercury^II-mediated formation of thymine-Hg^II-thymine base pairs in DNA duplexes

Yoko Miyake, Humika Togashi, Mitsuru Tashiro, Hiroshi Yamaguchi, Shuji Oda, Megumi Kudo, Yoshiyuki Tanaka, Yoshinori Kondo, Ryuichi Sawa, Takashi Fujimoto, Tomoya Machinami, Akira Ono

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

873 Citations (Scopus)

Abstract

The very specific binding of the Hg^II ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-Hg^II-thymine pairs.

Original language	English
Pages (from-to)	2172-2173
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	7
DOIs	https://doi.org/10.1021/ja056354d
Publication status	Published - 2006 Feb 22

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja056354d

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Mercury^II-mediated formation of thymine-Hg^II-thymine base pairs in DNA duplexes. / Miyake, Yoko; Togashi, Humika; Tashiro, Mitsuru; Yamaguchi, Hiroshi; Oda, Shuji; Kudo, Megumi; Tanaka, Yoshiyuki; Kondo, Yoshinori; Sawa, Ryuichi; Fujimoto, Takashi; Machinami, Tomoya; Ono, Akira.

In: Journal of the American Chemical Society, Vol. 128, No. 7, 22.02.2006, p. 2172-2173.

Research output: Contribution to journal › Article › peer-review

Miyake, Yoko ; Togashi, Humika ; Tashiro, Mitsuru ; Yamaguchi, Hiroshi ; Oda, Shuji ; Kudo, Megumi ; Tanaka, Yoshiyuki ; Kondo, Yoshinori ; Sawa, Ryuichi ; Fujimoto, Takashi ; Machinami, Tomoya ; Ono, Akira. / Mercury^II-mediated formation of thymine-Hg^II-thymine base pairs in DNA duplexes. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 7. pp. 2172-2173.

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author = "Yoko Miyake and Humika Togashi and Mitsuru Tashiro and Hiroshi Yamaguchi and Shuji Oda and Megumi Kudo and Yoshiyuki Tanaka and Yoshinori Kondo and Ryuichi Sawa and Takashi Fujimoto and Tomoya Machinami and Akira Ono",

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AU - Oda, Shuji

AU - Kudo, Megumi

AU - Tanaka, Yoshiyuki

AU - Kondo, Yoshinori

AU - Sawa, Ryuichi

AU - Fujimoto, Takashi

AU - Machinami, Tomoya

AU - Ono, Akira

PY - 2006/2/22

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AB - The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.

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Mercury^II-mediated formation of thymine-Hg^II-thymine base pairs in DNA duplexes

Abstract

ASJC Scopus subject areas

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