MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes

Yoko Miyake, Humika Togashi, Mitsuru Tashiro, Hiroshi Yamaguchi, Shuji Oda, Megumi Kudo, Yoshiyuki Tanaka, Yoshinori Kondo, Ryuichi Sawa, Takashi Fujimoto, Tomoya Machinami, Akira Ono

Research output: Contribution to journalArticlepeer-review

818 Citations (Scopus)

Abstract

The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.

Original languageEnglish
Pages (from-to)2172-2173
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number7
DOIs
Publication statusPublished - 2006 Feb 22

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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